Type 2 diabetes mellitus was a degeneration disease which become health problem in Indonesia as well as in the world. because of  that DM type 2 cases have increased year by years, there are some risk increasing welfare. change of food habit & less physical activity that factor to predisposition in increase incidence DM type 2

Keywords : DM tipe2. hyperglycemia.endothel.PARP.ICAM-1.NO.GPX

Abstract

The brain is one of the main targets hypertension. However, little is known about the association hypertension to motor dysfunction. Also the association interleukin-6 (IL- 6), TNF-o, nitic oxide and glutamate to motor dysfunction is still controversion The purpose of this study is to measure the association motor dysfunction to hlpertension and relate to interleukin-6 (IL-6), TNF<lo nitric oxide and glutamate

Key Words : hypertension, nitric oxide, motor dysfunction

Abstract

Hypertension is one major public health problem in Indonesia and other countries in the World. The main factor that involves in the pathophysiology of essential hypertension is the interaction between genetic and environmental factor . eNOS 3 gene is one of the important genes which is related to the high prevalence of HET. This gene  expresses the NbS enanoe which regulates the spthesis of NO in human body. This enzyme causes vasodilatation, which decreases peripheral resistant and blood pressure.

key words : essential hlpertension, eNOS3 gene and nitric oxide plasma level

abstract