Hypertension is one major public health problem in Indonesia and other countries in the World. The main factor that involves in the pathophysiology of essential hypertension is the interaction between genetic and environmental factor . eNOS 3 gene is one of the important genes which is related to the high prevalence of HET. This gene expresses the NbS enanoe which regulates the spthesis of NO in human body. This enzyme causes vasodilatation, which decreases peripheral resistant and blood pressure.
key words : essential hlpertension, eNOS3 gene and nitric oxide plasma level